Comparison of fluconazole and amphotericin B for treatment of experimental Candida endocarditis caused by non-C. albicans strains.

نویسندگان

  • M D Witt
  • T Imhoff
  • C Li
  • A S Bayer
چکیده

Amphotericin B and fluconazole were compared for the treatment of experimental Candida endocarditis caused by Candida tropicalis and C. parapsilosis. Rabbits received no therapy, amphotericin B (1 mg/kg of body weight per day intravenously), or fluconazole (100 mg/kg/day intraperitoneally) for either 11 or 21 days. Against both species, amphotericin B and fluconazole were equally effective overall; however, amphotericin B was more rapidly fungicidal than fluconazole in vivo against C. tropicalis.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 37 9  شماره 

صفحات  -

تاریخ انتشار 1993